Association of an allele on chromosome 9 and abdominal aortic aneurysm
Date
2010
Authors
Biros, E.
Cooper, M.
Palmer, L.
Walker, P.
Norman, P.
Golledge, J.
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Atherosclerosis, 2010; 212(2):539-542
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Erik Biros, Matthew Cooper, Lyle J. Palmer, Philip J. Walker, Paul E. Norman, Jonathan Golledge
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Abstract
<h4>Objective</h4>Abdominal aortic aneurysm (AAA) has been recognized as a multi-factorial disease with both genetic and environmental risk factors. A locus residing within non-coding DNA on chromosome 9p21.3 has recently been associated with AAA. To further investigate the significance of this site for AAA, we performed an association study on a large group of 3371 men aged 65-83 years of whom 513 had an AAA.<h4>Methods</h4>All men were assessed for other risk factors in a uniform way and an ultrasound of the abdominal aorta was performed.<h4>Results</h4>Our findings validated the strong association of the chromosome 9p21.3 SNPs rs10757278 and rs1333049 with AAA and demonstrated the upregulation of LINE-1 elements at the site of AAA.<h4>Conclusion</h4>This study confirms a reproducible association between risk alleles on chromosome 9p21.3 and AAA. We also provide preliminary evidence for an association of LINE-1 elements with AAA which will require further investigation.
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.