FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells

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dc.contributor.authorMcInnes, N.
dc.contributor.authorSadlon, T.
dc.contributor.authorBrown, C.
dc.contributor.authorPederson, S.
dc.contributor.authorBeyer, M.
dc.contributor.authorSchultze, J.
dc.contributor.authorMcColl, S.
dc.contributor.authorGoodall, G.
dc.contributor.authorBarry, S.
dc.date.issued2012
dc.description.abstractThe transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target of FOXP3 repression, but that FOXP3 also induces two miRs, miR-7 and miR-155, which specifically target the 3′-UTR of SATB1 to further regulate its expression. We conclude that FOXP3-regulated miRs form part of the mechanism by which FOXP3 prevents the transformation of the healthy breast epithelium to a cancerous phenotype. Approaches aimed at restoring FOXP3 function and the miRs it regulates could help provide new approaches to target breast cancer.
dc.description.statementofresponsibilityN McInnes, TJ Sadlon, CY Brown, S Pederson, M Beyer, JL Schultze, S McColl, GJ Goodall and SC Barry
dc.identifier.citationOncogene, 2012; 31(8):1045-1054
dc.identifier.doi10.1038/onc.2011.293
dc.identifier.issn0950-9232
dc.identifier.issn1476-5594
dc.identifier.orcidSadlon, T. [0000-0002-4821-2462]
dc.identifier.orcidPederson, S. [0000-0001-8197-3303]
dc.identifier.orcidMcColl, S. [0000-0003-0949-4660]
dc.identifier.orcidGoodall, G. [0000-0003-1294-0692]
dc.identifier.orcidBarry, S. [0000-0002-0597-7609]
dc.identifier.urihttp://hdl.handle.net/2440/71476
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/565314
dc.rights© 2012 Macmillan Publishers Limited
dc.source.urihttps://doi.org/10.1038/onc.2011.293
dc.subjectSATB1
dc.subjectFOXP3
dc.subjectmicroRNA
dc.subjectgene regulation networks
dc.subjectbreast cancer
dc.subjecttumour suppressor
dc.titleFOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells
dc.typeJournal article
pubs.publication-statusPublished

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