Optimizing Arsenic Therapy by Selectively Targeting Leukemia Cells

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dc.contributor.authorCarrall, J.A.
dc.contributor.authorLie, W.
dc.contributor.authorLambert, J.M.
dc.contributor.authorHarris, H.H.
dc.contributor.authorLai, B.
dc.contributor.authorDillon, C.T.
dc.date.issued2023
dc.descriptionPublished: August18, 2023
dc.description.abstractArsenic, in the simple form of arsenic trioxide, is currently marketed for the treatment of acute promyelocytic leukemia. Due to the multifaceted mechanisms of action of arsenic, it has also shown promise in other types of leukemias but is hindered by its toxic effects toward normal cells. This research has aimed to determine whether tumor-homing peptide complexes of arsenic can be designed and developed to strategically target specific cancers. The end goal is to achieve dose reduction and decreased side effects of the resultant arsenic therapeutic agent. In this article, we present the synthesis, characterization, and stability studies of a new class of As-peptide complexes designed to target leukemia. In vitro biological studies of the most stable complex show 1000 times greater toxicity toward leukemia cells over human blood cells, indicating potential for progression to in vivo studies.
dc.description.statementofresponsibilityJudith A. Carrall, Wilford Lie, Jacob M. Lambert, Hugh H. Harris, Barry Lai, and Carolyn T. Dillon
dc.identifier.citationJournal of Medicinal Chemistry, 2023; 66(17):12101-12114
dc.identifier.doi10.1021/acs.jmedchem.3c00676
dc.identifier.issn0022-2623
dc.identifier.issn1520-4804
dc.identifier.orcidHarris, H.H. [0000-0002-3472-8628]
dc.identifier.urihttps://hdl.handle.net/2440/139417
dc.language.isoen
dc.publisherAmerican Chemical Society (ACS)
dc.relation.granthttp://purl.org/au-research/grants/arc/LE0989759
dc.relation.granthttp://purl.org/au-research/grants/arc/LE110100174
dc.rights© 2023 American Chemical Society
dc.source.urihttps://doi.org/10.1021/acs.jmedchem.3c00676
dc.subjectArsenic; Cells; Monomers; Peptides and proteins; Stability
dc.titleOptimizing Arsenic Therapy by Selectively Targeting Leukemia Cells
dc.typeJournal article
pubs.publication-statusPublished

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