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Recent advances into understanding some aspects of the structure and function of mammalian and avian lungs

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dc.contributor.authorMaina, J.N.
dc.contributor.authorWest, J.B.
dc.contributor.authorOrgeig, S.
dc.contributor.authorFoot, N.J.
dc.contributor.authorDaniels, C.B.
dc.contributor.authorKiama, S.G.
dc.contributor.authorGehr, P.
dc.contributor.authorMühlfeld, C.
dc.contributor.authorBlank, F.
dc.contributor.authorMüller, L.
dc.contributor.authorLehmann, A.
dc.contributor.authorBrandenberger, C.
dc.contributor.authorRothen Rutishauser, B.
dc.date.issued2010
dc.description.abstractRecent findings are reported about certain aspects of the structure and function of the mammalian and avian lungs that include(a) the architecture of the air capillaries (ACs) and the blood capillaries (BCs); (b) the pulmonary blood capillary circulatory dynamics; (c) the adaptive molecular, cellular, biochemical,compositional, and developmental characteristics of the surfactant system; (d) the mechanisms of the translocation of fine and ultra fine particles across the airway epithelial barrier; and (e) the particle-cell interactions in the pulmonary airways. In the lung of the Muscovy duck Cairina moschata, at least, the ACs are rotund structures that are interconnected by narrow cylindrical sections, while the BCs comprise segments that are almost as long as they are wide. In contrast to the mammalian pulmonary BCs, which are highly compliant, those of birds practically behave like rigid tubes. Diving pressure has been a very powerful directional selection force that has influenced phenotypic changes in surfactant composition and function in lungs of marine mammals. After nanosized particulates are deposited on the respiratory tract of healthy human subjects, some reach organs such as the brain with potentially serious health implications. Finally, in the mammalian lung, dendritic cells of the pulmonary airways are powerful agents in engulfing deposited particles, and in birds, macrophages and erythrocytes are ardent phagocytizing cellular agents. The morphology of the lung that allows it to perform different functions - including gas exchange, ventilation of the lung by being compliant, defense, and secretion of important pharmacological factors - is reflected in its "compromise design."
dc.identifier.citationPhysiological and Biochemical Zoology, 2010; 83(5):792-807
dc.identifier.doi10.1086/652244
dc.identifier.issn1522-2152
dc.identifier.issn1537-5293
dc.identifier.orcidFoot, N.J. [0000-0002-6567-9283]
dc.identifier.urihttps://hdl.handle.net/1959.8/118161
dc.language.isoen
dc.publisherUniversity of Chicago Press
dc.relation.fundingARC
dc.relation.fundingNational Institutes of Health R01 HL 60968
dc.relation.fundingNational Research Foundation of South Africa
dc.relation.fundingSwiss National Science Foundation
dc.rightsCopyright 2010 by The University of Chicago
dc.source.urihttps://doi.org/10.1086/652244
dc.subjectlung
dc.subjectlung gas
dc.subjectmammal
dc.subjecthemodynamics
dc.subjectBlood-Air Barrier
dc.subjectCapillaries
dc.subjectAnimals
dc.subjectBirds
dc.subjectMammals
dc.subjectHumans
dc.subjectPhysiology, Comparative
dc.subjectRegional Blood Flow
dc.titleRecent advances into understanding some aspects of the structure and function of mammalian and avian lungs
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12143326180001831 13143321960001831 9915910551701831_53108835960001831.pdf
ror.mmsid9915910551701831

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