BAM-matcher: a tool for rapid NGS sample matching

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dc.contributor.authorWang, P.
dc.contributor.authorParker, W.
dc.contributor.authorBranford, S.
dc.contributor.authorSchreiber, A.
dc.date.issued2016
dc.description.abstractThe standard method used by high-throughput genome sequencing facilities for detecting mislabelled samples is to use independently generated high-density SNP data to determine sample identity. However, as it has now become commonplace to have multiple samples sequenced from the same source, such as for analysis of somatic variants using matched tumour and normal samples, we can directly use the genotype information inherent in the sequence data to match samples and thus bypass the need for additional laboratory testing. Here we present BAM-matcher, a tool that can rapidly determine whether two BAM files represent samples from the same biological source by comparing their genotypes. BAM-matcher is designed to be simple to use, provides easily interpretable results, and is suitable for deployment at early stages of data processing pipelines.BAM-matcher is licensed under the Creative Commons by Attribution license, and is available from: https://bitbucket.org/sacgf/bam-matcherSupplementary data are available at Bioinformatics online.paul.wang@sa.gov.au.
dc.description.statementofresponsibilityPaul P.S. Wang, Wendy T. Parker, Susan Branford, Andreas W. Schreiber
dc.identifier.citationBioinformatics, 2016; 32(17):2699-2701
dc.identifier.doi10.1093/bioinformatics/btw239
dc.identifier.issn1367-4803
dc.identifier.issn1460-2059
dc.identifier.orcidBranford, S. [0000-0002-1964-3626] [0000-0002-5095-7981]
dc.identifier.orcidSchreiber, A. [0000-0002-9081-3405]
dc.identifier.urihttp://hdl.handle.net/2440/107971
dc.language.isoen
dc.publisherOxford University Press
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1027531
dc.rights© The Author 2016. Published by Oxford University Press. All rights reserved.
dc.source.urihttps://doi.org/10.1093/bioinformatics/btw239
dc.subjectSequence Analysis, DNA
dc.titleBAM-matcher: a tool for rapid NGS sample matching
dc.typeJournal article
pubs.publication-statusPublished

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