Fetal and maternal drug metabolism in complicated pregnancies /
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(Published version)
Date
2019
Authors
McBride, Grace
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thesis
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Abstract
Up to 99% of pregnant women take medications, and 10% of babies are affected by intrauterine growth restriction (IUGR), with additional medications often required by IUGR babies and their mothers. The IUGR fetus undergoes a range of adaptations and thus, we hypothesise that the activity of drug metabolising enzymes in these mothers and fetuses may be altered. We performed a literature review of changes to fetal drug metabolism due to IUGR, and the physiologic causes that these may be, and in vivo and in vitro studies of drug metabolising enzymes in the mother and her IUGR fetus and normal pregnancies.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (Masters by research(Medical Science))--University of South Australia, 2019.
Provenance
Copyright 2019 Grace M. McBride.
Description
1 ethesis (xvi, 103 pages) :
colour illustrations, charts (some colour)
Includes bibliographical references (pages 92-103)
colour illustrations, charts (some colour)
Includes bibliographical references (pages 92-103)
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506 0#$fstar $2Unrestricted online access