Effects of ginger on gastric emptying and motility in healthy humans

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dc.contributor.authorWu, K.
dc.contributor.authorRayner, C.
dc.contributor.authorChuah, S.
dc.contributor.authorChangchien, C.
dc.contributor.authorLu, S.
dc.contributor.authorChiu, Y.
dc.contributor.authorChiu, K.
dc.contributor.authorLee, C.
dc.date.issued2008
dc.description.abstract<h4>Objective</h4>Ginger has been reported to improve upper gastrointestinal symptoms. Little information about the effects of ginger on gastric motor function, exists, however. Our aim was to investigate the effects of ginger on gastric emptying, antral motility, proximal gastric dimensions, and postprandial symptoms.<h4>Methods</h4>Twenty-four healthy volunteers were studied twice in a randomized double-blind manner. After an 8 h fast, the volunteers ingested three ginger capsules (total 1200 mg) or placebo, followed after 1 h by 500 ml low-nutrient soup. Antral area, fundus area and diameter, and the frequency of antral contractions were measured using ultrasound at frequent intervals over 90 min, and the gastric half-emptying time was calculated from the change in antral area. Gastrointestinal sensations and appetite were scored using visual analog questionnaires. Data are expressed in terms of mean+/-standard error.<h4>Results</h4>Antral area decreased more rapidly (P<0.001) and the gastric half-emptying time was less after ginger than placebo ingestion (13.1+/-1.1 vs. 26.7+/-3.1 min, P<0.01), whereas the frequency of antral contractions was greater (P<0.005). Fundus dimensions did not differ, and there was no significant difference in any gastrointestinal symptoms.<h4>Conclusion</h4>Ginger accelerates gastric emptying and stimulates antral contractions in healthy volunteers. These effects could potentially be beneficial in symptomatic patient groups.
dc.description.statementofresponsibilityWu, Keng-Liang; Rayner, Christopher K.; Chuah, Seng-Kee; Changchien, Chi-Sin; Lu, Sheng-Nan; Chiu, Yi-Chun; Chiu, King-Wah; Lee, Chuan-Mo
dc.identifier.citationEuropean Journal of Gastroenterology and Hepatology, 2008; 20(5):436-440
dc.identifier.doi10.1097/MEG.0b013e3282f4b224
dc.identifier.issn0954-691X
dc.identifier.issn1473-5687
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]
dc.identifier.urihttp://hdl.handle.net/2440/53521
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.source.urihttps://doi.org/10.1097/meg.0b013e3282f4b224
dc.subjectPyloric Antrum
dc.subjectHumans
dc.subjectPlant Extracts
dc.subjectPhytotherapy
dc.subjectDouble-Blind Method
dc.subjectSensation
dc.subjectGastrointestinal Motility
dc.subjectGastric Emptying
dc.subjectPostprandial Period
dc.subjectMuscle Contraction
dc.subjectAdult
dc.subjectMale
dc.subjectZingiber officinale
dc.titleEffects of ginger on gastric emptying and motility in healthy humans
dc.typeJournal article
pubs.publication-statusPublished

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