Reduced motor cortex plasticity following inhibitory rTMS in older adults
| dc.contributor.author | Todd, G. | |
| dc.contributor.author | Kimber, T. | |
| dc.contributor.author | Ridding, M. | |
| dc.contributor.author | Semmler, J. | |
| dc.date.issued | 2010 | |
| dc.description.abstract | <h4>Objective</h4>Ageing is accompanied by diminished practice-dependent plasticity. We investigated the effect of age on another plasticity inducing paradigm, repetitive transcranial magnetic stimulation (rTMS).<h4>Methods</h4>Healthy young (n=15; 25+/-4 years) and old (n=15; 67+/-5 years) adults participated in two experiments. Motor evoked potentials (MEPs) were measured in the target muscle (first dorsal interosseus, FDI) and a remote muscle (abductor digiti minimi) during a set of single stimuli. Subjects then received real or sham inhibitory rTMS (intermittent subthreshold trains of 6Hz stimulation for 10min). MEPs were measured for 30min after rTMS.<h4>Results</h4>In young adults, MEPs in the target FDI muscle were approximately 15% smaller in the real rTMS experiment than in the sham rTMS experiment (P<0.026). In old adults, FDI MEP size did not differ between experiments.<h4>Conclusions</h4>Advancing age is associated with reduced efficacy of inhibitory rTMS.<h4>Significance</h4>This work has important implications for the potential therapeutic use of rTMS in stroke and neurological disease. | |
| dc.description.statementofresponsibility | Gabrielle Todd, Thomas E. Kimber, Michael C. Ridding and John G. Semmler | |
| dc.identifier.citation | Clinical Neurophysiology, 2010; 121(3):441-447 | |
| dc.identifier.doi | 10.1016/j.clinph.2009.11.089 | |
| dc.identifier.issn | 1388-2457 | |
| dc.identifier.issn | 1872-8952 | |
| dc.identifier.orcid | Ridding, M. [0000-0001-5657-9136] | |
| dc.identifier.orcid | Semmler, J. [0000-0003-0260-8047] | |
| dc.identifier.uri | http://hdl.handle.net/2440/57641 | |
| dc.language.iso | en | |
| dc.publisher | Elsevier Sci Ireland Ltd | |
| dc.rights | Copyright 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved | |
| dc.source.uri | https://doi.org/10.1016/j.clinph.2009.11.089 | |
| dc.subject | Age | |
| dc.subject | Repetitive transcranial magnetic stimulation | |
| dc.subject | Motor cortex | |
| dc.subject | Excitability | |
| dc.subject | Human | |
| dc.title | Reduced motor cortex plasticity following inhibitory rTMS in older adults | |
| dc.type | Journal article | |
| pubs.publication-status | Published |