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Efficient co-delivery of immiscible hydrophilic/hydrophobic chemotherapeutics by lipid emulsions for improved treatment of cancer

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dc.contributor.authorZhang, B.
dc.contributor.authorSong, Y.
dc.contributor.authorWang, T.
dc.contributor.authorYang, S.
dc.contributor.authorZhang, J.
dc.contributor.authorLiu, Y.
dc.contributor.authorZhang, N.
dc.contributor.authorGarg, S.
dc.date.issued2017
dc.descriptionData source: Supplementary materials, https://doi.org/10.2147/IJN.S129091
dc.description.abstractCombinational nanomedicine is becoming a topic of much interest in cancer therapy, although its translation into the clinic remains extremely challenging. One of the main obstacles lies in the difficulty to efficiently co-deliver immiscible hydrophilic/hydrophobic drugs into tumor sites. The aim of this study was to develop co-loaded lipid emulsions (LEs) to co-deliver immiscible hydrophilic/hydrophobic drugs to improve cancer therapy and to explore the co-delivery abilities between co-loaded LEs and mixture formulation. Multiple oxaliplatin/irinotecan drug– phospholipid complexes (DPCs) were formulated. Co-loaded LEs were prepared using DPC technique to efficiently encapsulate both drugs. Co-loaded LEs exhibited uniform particle size distribution, desired stability and synchronous release profiles in both drugs. Co-loaded LEs demonstrated superior anti-tumor activity compared with the simple solution mixture and the mixture of single-loaded LEs. Furthermore, co-loaded nanocarriers could co-deliver both drugs into the same cells more efficiently and exhibited the optimized synergistic effect. These results indicate that co-loaded LEs could be a desired formulation for enhanced cancer therapy with potential application prospects. The comparison between co-loaded LEs and mixture formulation is significant for pharmaceutical designs aimed at co-delivery of multiple drugs.
dc.identifier.citationInternational Journal of Nanomedicine, 2017; 12:2871-2886
dc.identifier.doi10.2147/IJN.S129091
dc.identifier.issn1176-9114
dc.identifier.issn1178-2013
dc.identifier.orcidGarg, S. [0000-0001-7253-2629]
dc.identifier.urihttps://hdl.handle.net/11541.2/126361
dc.language.isoen
dc.publisherDove Medical Press
dc.relation.fundingChina-Australia Centre for Health Sciences Research (CACHSR) 2014GJ10
dc.relation.fundingScience and Technology Development Project of Shandong Province 2014GGE27121
dc.rightsCopyright 2017 Zhang et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. (https://creativecommons.org/licenses/by-nc/3.0/)
dc.source.urihttps://doi.org/10.2147/IJN.S129091
dc.subjectcancer
dc.subjectcombination therapy
dc.subjectco-delivery
dc.subjectlipid emulsions
dc.subjectdrug–phospholipidcomplex
dc.titleEfficient co-delivery of immiscible hydrophilic/hydrophobic chemotherapeutics by lipid emulsions for improved treatment of cancer
dc.typeJournal article
pubs.publication-statusPublished
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ror.mmsid9916129210901831

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