Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy
Date
2004
Authors
Tan, N.
Heron, S.
Scheffer, I.
Pelekanos, J.
McMahon, J.
Vears, D.
Mulley, J.
Berkovic, S.
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Advisors
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Journal article
Citation
Neurology, 2004; 63(6):1090-1092
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Abstract
Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.
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Copyright © 2004 American Academy of Neurology