Opioid-induced central immune signaling: implications for opioid analgesia

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dc.contributor.authorGrace, P.M.
dc.contributor.authorMaier, S.F.
dc.contributor.authorWatkins, L.R.
dc.date.issued2015
dc.description.abstractDespite being the mainstay of pain management, opioids are limited in their clinical utility by adverse effects, such as tolerance and paradoxical hyperalgesia. Research of the past 15 years has extended beyond neurons, to implicate central nervous system immune signaling in these adverse effects. This article will provide an overview of these central immune mechanisms in opioid tolerance and paradoxical hyperalgesia, including those mediated by Toll-like receptor 4, purinergic, ceramide, and chemokine signaling. Challenges for the future, as well as new lines of investigation will be highlighted.
dc.description.statementofresponsibilityPeter M. Grace, Steven F. Maier, Linda R. Watkins
dc.identifier.citationHeadache, 2015; 55(4):475-489
dc.identifier.doi10.1111/head.12552
dc.identifier.issn0017-8748
dc.identifier.issn1526-4610
dc.identifier.orcidGrace, P.M. [0000-0002-8999-1220]
dc.identifier.urihttps://hdl.handle.net/2440/134130
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1054091
dc.rights© 2015 American Headache Society
dc.source.urihttps://doi.org/10.1111/head.12552
dc.subjectTLR4; P2X4 receptor; P2X7 receptor; opioid receptor; allodynia; hyperalgesia
dc.subject.meshCentral Nervous System
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshHyperalgesia
dc.subject.meshAnalgesics, Opioid
dc.subject.meshAnalgesia
dc.subject.meshSignal Transduction
dc.subject.meshDrug Tolerance
dc.subject.meshToll-Like Receptor 4
dc.titleOpioid-induced central immune signaling: implications for opioid analgesia
dc.typeJournal article
pubs.publication-statusPublished

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