Use of heated humidification during nasal CPAP titration in obstructive sleep apnoea syndrome

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dc.contributor.authorDuong, M.
dc.contributor.authorJayaram, L.
dc.contributor.authorCamfferman, D.
dc.contributor.authorCatcheside, P.
dc.contributor.authorMykytyn, I.
dc.contributor.authorMcEvoy, R.
dc.date.issued2005
dc.description.abstractNasal symptoms associated with the use of nasal continuous positive airway pressure (nCPAP) in obstructive sleep apnoea (OSA) can adversely impact on patients' tolerance, acceptance and adherence to nCPAP therapy. Regular use of heated humidification is effective in alleviating these symptoms and improve patient comfort. In a randomised, parallel, double-blinded, controlled study, the present authors examined the use of heated humidification during a single night laboratory nCPAP titration in untreated OSA patients and its effect on nasal symptoms, nasal airway resistance (NAR), effective pressure and treatment tolerability and acceptance. Baseline characteristics of subjects (n=70) receiving placebo and humidification were (mean+/-sem): age 51.2+/-2.2 versus 50.6+/-1.6 yrs; body mass index 33.6+/-0.9 versus 35.2+/-0.9 kg.m-2; Epworth Sleepiness Scale 10.8+/-1.0 versus 11.3+/-0.7; and apnoea-hypopnoea index 43.5+/-4.6 versus 44.4+/-4.1 events.h-1. Total inspiratory NAR, before (0.36+/-0.09 (placebo) versus 0.33+/-0.09 kPa.L-1.s-1) and after nCPAP (0.47+/-0.11 versus 0.29+/-0.04 kPa.L-1.s-1) were not significantly different between the groups. No difference was found in the frequency and severity of nasopharyngeal symptoms, therapeutic pressure and subjective response to nCPAP. In conclusion, heated humidification during the initial nasal continuous positive airway pressure titration offers no additional benefit in nasal physiology, symptoms or subjective response to nasal continuous positive airway pressure, and, therefore, should not be routinely recommended.
dc.identifier.citationEuropean Respiratory Journal, 2005; 26(4):679-685
dc.identifier.doi10.1183/09031936.05.00131504
dc.identifier.issn0903-1936
dc.identifier.issn1399-3003
dc.identifier.orcidCatcheside, P. [0000-0002-9372-6788]
dc.identifier.orcidMcEvoy, R. [0000-0002-5759-0094]
dc.identifier.urihttp://hdl.handle.net/2440/27559
dc.language.isoen
dc.publisherEuropean Respiratory Soc Journals Ltd
dc.source.urihttps://doi.org/10.1183/09031936.05.00131504
dc.subjectHumans
dc.subjectSleep Apnea, Obstructive
dc.subjectTreatment Outcome
dc.subjectContinuous Positive Airway Pressure
dc.subjectDouble-Blind Method
dc.subjectHeating
dc.subjectHumidity
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.titleUse of heated humidification during nasal CPAP titration in obstructive sleep apnoea syndrome
dc.typeJournal article
pubs.publication-statusPublished

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