Antagonistic effects of cadmium on lead accumulation in pregnant and non-pregnant mice
Date
2012
Authors
Smith, E.
Gancarz, D.
Rofe, A.
Kempson, I.M.
Weber, J.
Juhasz, A.L.
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Journal article
Citation
Journal of Hazardous Materials, 2012; 199-200:453-456
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Abstract
People are frequently exposed to combinations of contaminants but there is a paucity of data on the effects of mixed contaminants at low doses. This study investigated the influence of cadmium (Cd) on lead (Pb) accumulation in pregnant and non-pregnant mice following exposure to contaminated soil. Exposure to Pb from contaminated soils increased Pb accumulation in both pregnant and non-pregnant mice compared to unexposed control animals (pregnant and non-pregnant). Lead accumulation in the liver and kidneys of exposure pregnant mice (40 ± 15 mg Pb kg(-1)) was significantly higher (P<0.05) than concentrations detected in control pregnant mice (<1 mg Pb kg(-1)). The presence of Cd in contaminated soil had a major effect on the Pb and Fe accumulation in the kidneys and liver, respectively. This study shows that Pb uptake is mediated by the presence of Cd in the co-contaminated soil and demonstrates that further research is required to investigate the influence of co-contaminants on human exposure at sub-chronic concentrations.
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Dissertation Note
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Copyright 2011 Elsevier B.V.