Macrophage contributions to ovarian function

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dc.contributor.authorWu, R.
dc.contributor.authorVan Der Hoek, K.
dc.contributor.authorRyan, N.
dc.contributor.authorNorman, R.
dc.contributor.authorRobker, R.
dc.date.issued2004
dc.description© European Society of Human Reproduction and Embryology 2004; all rights reserved
dc.description.abstractMacrophages are multifunctional cells that play key roles in the immune response and are abundant throughout female reproductive tissues. Macrophages are identified in tissues by their expression of cell surface receptors and can execute diverse functional activities, including phagocytosis and degradation of foreign antigens, matrix dissolution and tissue remodelling, and production and secretion of cytokines, chemokines and growth factors. Their specific localization and variations in distribution in the ovary during different stages of the cycle, as well as their presence in peri-ovulatory human follicular fluid, suggest that macrophages play diverse roles in intra-ovarian events including folliculogenesis, tissue restructuring at ovulation and corpus luteum formation and regression. This review presents the existing evidence for the regulation of ovarian function by macrophages and macrophage-derived products, highlighting the implications of these cells in ovarian diseases, particularly polycystic ovary syndrome, endometriosis and premature ovarian failure.
dc.description.statementofresponsibilityRuijin Wu, Kylie H. Van der Hoek, Natalie K. Ryan, Robert J. Norman and Rebecca L. Robker
dc.identifier.citationHuman Reproduction Update, 2004; 10(2):119-133
dc.identifier.doi10.1093/humupd/dmh011
dc.identifier.issn1355-4786
dc.identifier.issn1460-2369
dc.identifier.orcidVan Der Hoek, K. [0000-0002-7904-7340]
dc.identifier.orcidNorman, R. [0000-0002-3118-3896]
dc.identifier.orcidRobker, R. [0000-0002-1538-4604]
dc.identifier.urihttp://hdl.handle.net/2440/8236
dc.language.isoen
dc.publisherOxford Univ Press
dc.source.urihttps://doi.org/10.1093/humupd/dmh011
dc.subjectCytokine
dc.subjectmacrophage
dc.subjectovary
dc.subjectovulation
dc.subjectpolycystic ovary syndrome
dc.titleMacrophage contributions to ovarian function
dc.typeJournal article
pubs.publication-statusPublished

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