Unexpected mechanisms of action for a cytokine receptor-blocking antibody.
Date
2014
Authors
Hercus, T.
Broughton, S.
Hardy, M.
Nero, T.
Wilson, N.
Parker, M.
Lopez, A.
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Advisors
Journal Title
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Type:
Journal article
Citation
Molecular & Cellular Oncology, 2014; 1(4):e969129-e969129
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Conference Name
Abstract
CSL362 is a humanized interleukin-3 (IL-3)-neutralizing monoclonal antibody with enhanced effector function that binds the α subunit of the IL-3 receptor (IL3Rα). The crystal structure of an IL3Rα:CSL362 complex shows that IL3Rα adopts "open" and "closed" conformations. CSL362 blocks IL-3 function through both IL3Rα conformations but via distinct and unexpected mechanisms.
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Dissertation Note
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Copyright 2014 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s)have been asserted. (http://creativecommons.org/licenses/by-nc/3.0/)