Red blood cell transfusions at 21 days of age or older in previously transfusion-naive very preterm infants: association with neonatal outcomes

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dc.contributor.authorKeir, A.
dc.contributor.authorAziz, K.
dc.contributor.authorMcMillan, D.
dc.contributor.authorMonterrosa, L.
dc.contributor.authorOjah, C.
dc.contributor.authorLee, S.
dc.contributor.authorShah, P.
dc.date.issued2015
dc.description.abstractThis study aims to assess the association of red blood cell (RBC) transfusion in a cohort of preterm infants with mortality, retinopathy of prematurity (ROP), and chronic lung disease (CLD) transfused at ≥21 days of life.This retrospective cohort study included infants born at <30 weeks' gestation who survived ≥21 days, had not received any RBC transfusions before reaching 21 days of age, and were admitted to participating units in the Canadian neonatal network (2003-2009).Out of the 3,799 eligible infants, 3,309 infants did not receive RBC transfusion at  ≥21 days of age, whereas 490 received transfusion at  ≥21 days of age. Infants who did not receive RBC transfusion/s at  ≥21 days of age had higher birth weight (p<0.01) and higher gestational age at the time of birth (p<0.01) as compared with those who received transfusion/s at ≥21 days of age. Receipt of RBC transfusion/s at  ≥21 days of age was not associated with mortality (adjusted odds ratio [AOR] 1.20; 95% confidence interval [CI] 0.33-4.34) or severe ROP (AOR 1.02; 95% CI 0.59-1.77) but was associated with increased odds of CLD (AOR 1.78; 95% CI 1.43-2.22).RBC transfusion/s at  ≥21 days of age in previously transfusion-naive preterm infants was associated with increased odds of CLD but not with ROP or mortality.
dc.description.statementofresponsibilityAmy Keir, Khalid Aziz, Douglas McMillan, Luis Monterrosa, Cecil Ojah, Shoo Lee, Prakesh S. Shah, on behalf of the Canadian Neonatal Network
dc.identifier.citationAmerican Journal of Perinatology, 2015; 32(12):1139-1144
dc.identifier.doi10.1055/s-0035-1549295
dc.identifier.issn0735-1631
dc.identifier.issn1098-8785
dc.identifier.orcidKeir, A. [0000-0003-1692-5676]
dc.identifier.urihttp://hdl.handle.net/2440/102876
dc.language.isoen
dc.publisherThieme
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.1055/s-0035-1549295
dc.subjectInfant; newborn; premature; red blood cell transfusion; adverse affects
dc.titleRed blood cell transfusions at 21 days of age or older in previously transfusion-naive very preterm infants: association with neonatal outcomes
dc.typeJournal article
pubs.publication-statusPublished

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