Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein

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dc.contributor.authorFinnie, J.
dc.contributor.authorManavis, J.
dc.date.issued2017
dc.description.abstractNeuroaxonal dystrophy (NAD) is a neurologic disorder of sheep characterized by accumulation of numerous axonal swellings (spheroids) in specific regions of the brainstem and spinal cord. Disruption of axonal transport, which is driven in anterograde and retrograde directions by the molecular motors, kinesin and dynein, respectively, is believed to contribute to spheroid development. Accordingly, we examined spheroids in ovine NAD cases immunohistochemically for kinesin and dynein and found both motor proteins, with dynein more strongly expressed than kinesin. Further investigations of the kinesin and dynein content of axonal spheroids in NAD, and other neurodegenerative disorders of domestic animals, could assist in better understanding the pathogenesis of these diseases.
dc.description.statementofresponsibilityJohn W. Finnie, Jim Manavis
dc.identifier.citationJournal of Veterinary Diagnostic Investigation, 2017; 29(6):852-855
dc.identifier.doi10.1177/1040638717721579
dc.identifier.issn1040-6387
dc.identifier.issn1943-4936
dc.identifier.orcidFinnie, J. [0000-0003-2277-1693]
dc.identifier.orcidManavis, J. [0000-0001-7381-7781] [0000-0003-1268-561X]
dc.identifier.urihttp://hdl.handle.net/2440/112385
dc.language.isoen
dc.publisherSAGE Publications
dc.rights© 2017 The Author(s)
dc.source.urihttps://doi.org/10.1177/1040638717721579
dc.subjectAxonal dystrophies
dc.subjectdynein
dc.subjectkinesin
dc.subjectsheep
dc.subjectneuroaxonal dystrophy
dc.titleAxonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein
dc.typeJournal article
pubs.publication-statusPublished

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