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The effect of recombinant follicle stimulating hormone (Gonal-F) on endogenous luteinizing hormone secretion in women

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dc.contributor.authorHull, M.
dc.contributor.authorLivesey, J.
dc.contributor.authorEvans, J.
dc.contributor.authorBenny, P.
dc.date.issued1998
dc.description.abstractParenteral administration of follicle stimulating hormone (FSH) has been shown to lower luteinizing hormone (LH) concentrations in women undergoing ovulation induction. This study was designed to explore the physiological mechanism of this effect. Seven healthy women were recruited into a double-blind placebo-controlled study. LH secretion, after the administration of variable i.v. boluses (37.5, 75 and 150 IU) of recombinant FSH (Gonal-F), was evaluated. LH was measured at 10 min intervals for 2 h before and 4 h after the FSH/placebo infusion. LH pulse frequency and amplitude were evaluated and there was no significant difference between control and trial cycles for each subject. A linear regression analysis revealed that in the group receiving 150 IU FSH, the mean plasma LH concentration decreased significantly due to a reduction tonic LH secretion. This could be a result of the suppression of secretion or an alteration of clearance. This decrease was not seen in the other dosage groups, revealing that above a dosage threshold, FSH reduced non-pulsatile LH secretion. Therefore the effect of FSH in this study exposed the likely presence of two components of LH concentration: an FSH-sensitive, non-pulsatile tonic secretion and a gonadotrophin- releasing hormone-stimulated, pulsatile release that is unaffected by FSH. Although an indirect effect involving ovarian regulation is not excluded, the rapidity of the effect suggests that FSH acts directly on the pituitary gland.
dc.description.statementofresponsibilityM. L. Hull, J. H. Livesey, J. J. Evans and P. S. Benny
dc.identifier.citationHuman Reproduction, 1998; 13(5):1139-1143
dc.identifier.doi10.1093/humrep/13.5.1139
dc.identifier.issn0268-1161
dc.identifier.issn1460-2350
dc.identifier.orcidHull, M. [0000-0003-1813-3971] [0000-0003-4660-4005]
dc.identifier.urihttp://hdl.handle.net/2440/65214
dc.language.isoen
dc.publisherOxford University Press
dc.rights© European Society for Human Reproduction and Embryology
dc.source.urihttps://doi.org/10.1093/humrep/13.5.1139
dc.subjectanterior pituitary
dc.subjectfollicle stimulating hormone
dc.subjectgonadotrophin-releasing hormone
dc.subjectgonadotrophin surge attenuating factor
dc.subjectluteinizing hormone
dc.titleThe effect of recombinant follicle stimulating hormone (Gonal-F) on endogenous luteinizing hormone secretion in women
dc.typeJournal article
pubs.publication-statusPublished

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