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Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

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dc.contributor.authorSingh, B.
dc.contributor.authorMahajan, S.
dc.contributor.authorAbdella, S.
dc.contributor.authorKhan, R.
dc.contributor.authorGarg, S.
dc.date.issued2026
dc.description.abstractNeurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders. This review aims to provide a comprehensive overview of autophagy's role in neurodegenerative diseases, focusing on AD. The pathogenesis of AD involves the accumulation of misfolded proteins, such as beta-amyloid (Aβ) and tau, leading to neuronal dysfunction and cognitive impairment. Autophagy can be crucial in clearing these protein aggregates and maintaining cellular homeostasis. Nevertheless, autophagic dysregulation and mitochondrial dysfunction contribute to further progression of neurodegeneration. Furthermore, recent studies have demonstrated the therapeutic potential of several plant-based phytoconstituents and repurposed molecules that modulate autophagy. These compounds target both mTOR-dependent and independent pathways, highlighting their potential to alleviate disease pathology. This review aims to pave the way for future research and development in this field.
dc.identifier.citationMedicinal Research Reviews, online, 2026; 46(1):272-298
dc.identifier.doi10.1002/med.70013
dc.identifier.issn0198-6325
dc.identifier.issn1098-1128
dc.identifier.orcidGarg, S. [0000-0001-7253-2629]
dc.identifier.urihttps://hdl.handle.net/11541.2/44908
dc.language.isoen
dc.publisherWILEY
dc.relation.fundingCouncil of Australian University Librarians
dc.rightsCopyright 2025 The Authors. (http://creativecommons.org/licenses/by/4.0/) Access Condition Notes: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1002/med.70013
dc.subjectAnimals
dc.subjectHumans
dc.subjectAlzheimer Disease
dc.subjectSignal Transduction
dc.subjectAutophagy
dc.subjectAmyloid beta-Peptides
dc.titleExploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management
dc.typeJournal article
pubs.publication-statusAccepted
ror.mmsid9917076099701831

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