Fluorouracil-induced Hepatic Artery Spasm Preventing Yttrium-90 Microsphere Administration

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2008

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Townsend, A.
Price, T.
Patterson, K.
Pittman, K.

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Clinical Nuclear Medicine, 2008; 33(8):528-530

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Amanda Townsend, Timothy J. Price, Kevin Patterson, Ken Pittman

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Abstract

Coronary spasm is a recognized complication of fluorouracil (FU) chemotherapy. Spasm has been documented at other arterial sites with FU. SIR-spheres (radioactive yttrium-90 microspheres) are increasingly being used for hepatic colorectal metastasis. Various FU schedules are reported in the literature, and it is likely there will be coadministration with SIR-spheres. There is, however, little specific information in these reports as to the timing of FU and hepatic arterial spasm associated with infusion FU, which is a potential complication that should be considered.

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