1,2-dioxines containing tethered hydroxyl functionality as convenient precursors for pyran syntheses

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dc.contributor.authorAvery, T.
dc.contributor.authorCaiazza, D.
dc.contributor.authorCulbert, J.
dc.contributor.authorTaylor, D.
dc.contributor.authorTiekink, E.
dc.date.issued2005
dc.descriptionCopyright © 2005 American Chemical Society
dc.description.abstractA new method for the construction of tetrahydropyrans derived from readily available 1,2-dioxines containing a tethered hydroxyl moiety is described. The reaction proceeds via a base-catalyzed rearrangement of the 1,2-dioxines to either the isomeric cis or trans -hydroxy enones followed by intramolecular oxa-Michael addition of the tethered hydroxyl group.
dc.description.statementofresponsibilityThomas D. Avery, Daniela Caiazza, Julie A. Culbert, Dennis K. Taylor, and Edward R. T. Tiekink
dc.identifier.citationJournal of Organic Chemistry, 2005; 70(21):8344-8351
dc.identifier.doi10.1021/jo050806n
dc.identifier.issn0022-3263
dc.identifier.issn1520-6904
dc.identifier.orcidAvery, T. [0000-0001-6882-5461]
dc.identifier.orcidTaylor, D. [0000-0002-3302-4610] [0000-0002-4274-3983] [0000-0003-0633-7424]
dc.identifier.urihttp://hdl.handle.net/2440/17805
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.source.urihttps://doi.org/10.1021/jo050806n
dc.subjectHydroxyl Radical
dc.subjectHeterocyclic Compounds, 1-Ring
dc.subjectPyrans
dc.subjectAnticholesteremic Agents
dc.subjectMolecular Structure
dc.subjectAntimitotic Agents
dc.title1,2-dioxines containing tethered hydroxyl functionality as convenient precursors for pyran syntheses
dc.typeJournal article
pubs.publication-statusPublished

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