Discovery of a novel long terminal repeat (LTR2i-SS) in Sus Scrofa

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dc.contributor.authorLim, S.
dc.contributor.authorKortschak, R.
dc.contributor.authorAdelson, D.
dc.date.issued2014
dc.description.abstractLong terminal repeat (LTR) retrotransposons are transposable elements flanked by 5'/3' LTRs. They have a structure similar to endogenous retroviruses, but they lack the envelope (env) gene making them non-infectious. Long terminal repeats are motif-rich sequences and can act as bidirectional promoters or enhancers to regulate or inactivate genes by insertion. In this study, we identified a new chimeric LTR subfamily, LTR2i_SS, in the pig genome. This chimeric LTR family appears to be the ancestral form of the previously described LTR2_SS family. LTR2_SS appears to have deleted ~300 bp of un-annotated, ancestral sequence from LTR2i_SS. We identified no functional provirus sequences for either of these LTR types. LTR2i_SS sequences have been exapted into the untranslated regions of two protein-coding gene mRNAs. Both of these genes lie within previously mapped pig quantitative trait loci.
dc.description.statementofresponsibilitySim L. Lim, R. Daniel Kortschak and David L. Adelson
dc.identifier.citationAnimal Genetics, 2014; 45(3):367-372
dc.identifier.doi10.1111/age.12138
dc.identifier.issn0268-9146
dc.identifier.issn1365-2052
dc.identifier.orcidKortschak, R. [0000-0001-8295-2301]
dc.identifier.orcidAdelson, D. [0000-0003-2404-5636]
dc.identifier.urihttp://hdl.handle.net/2440/113886
dc.language.isoen
dc.publisherWiley
dc.rights© 2014 Stichting International Foundation for Animal Genetics
dc.source.urihttps://doi.org/10.1111/age.12138
dc.subjectExaptation; long terminal repeat; repetitive elements; retrotransposon; retrovirus
dc.titleDiscovery of a novel long terminal repeat (LTR2i-SS) in Sus Scrofa
dc.typeJournal article
pubs.publication-statusPublished

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