Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections

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dc.contributor.authorFlorido, M.
dc.contributor.authorMcColl, S.
dc.contributor.authorAppelberg, R.
dc.date.issued2009
dc.descriptionCopyright © 2009 Elsevier GmbH All rights reserved.
dc.description.abstractCD30 is a member of the tumor necrosis factor-receptor superfamily, a group of receptors known to act as accessory molecules in the development of the immune response. Control and CD30-deficient mice were aerogenically infected with Mycobacterium avium. Although the mycobacterial loads in the lungs were similar in both strains of mice, CD30-deficient animals exhibited delayed structuring of pulmonary granulomas and reduced recruitment of lymphocytes throughout a 240 days period of infection. Discrete alterations in the chemokine network were detected in the CD30-deficient animals although they showed no clear relation to the deficient inflammatory response. Thus CD30/CD153 interactions are involved in lung immune-mediated inflammation.
dc.description.statementofresponsibilityManuela Flórido, Shaun R. McColl and Rui Appelberg
dc.identifier.citationImmunobiology, 2009; 214(8):643-652
dc.identifier.doi10.1016/j.imbio.2008.12.002
dc.identifier.issn0171-2985
dc.identifier.issn1878-3279
dc.identifier.orcidMcColl, S. [0000-0003-0949-4660]
dc.identifier.urihttp://hdl.handle.net/2440/57069
dc.language.isoen
dc.publisherUrban & Fischer Verlag
dc.source.urihttps://doi.org/10.1016/j.imbio.2008.12.002
dc.subjectMycobacteria
dc.subjectT cells
dc.subjectCell-mediated immunity
dc.subjectLung
dc.titleDelayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections
dc.typeJournal article
pubs.publication-statusPublished

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