Effect of intra-articular infliximab on synovial membrane pathology in a patient with a seronegative spondyloarthropathy

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dc.contributor.authorAhern, M.
dc.contributor.authorCampbell, D.
dc.contributor.authorWeedon, H.
dc.contributor.authorPapangelis, V.
dc.contributor.authorSmith, M.
dc.date.issued2008
dc.description.abstractObjective: To demonstrate the efficacy of intra-articular infliximab in a patient with a persistent monarthritis who had previously had two arthroscopic synovectomies with limited success, and to determine the effect of intra-articular infliximab on synovial membrane pathology Method: Arthroscopic synovial biopsy specimens were collected before and after treatment with intra-articular infliximab. The synovial tissue was stained for a range of inflammatory cell subsets, cell adhesion molecules and cytokines using immunohistochemical techniques and quantified using digital image analysis and a semiquantitative scoring method. Results: Clinical improvement in the knee synovitis was seen after the first two intra-articular infliximab treatments, with a sustained clinical remission lasting for more than 12 months after the third treatment. Significant changes in cellular infiltration and expression of cytokines and cell adhesion molecules occurred as a result of treatment with intra-articular infliximab, with a reduction in some but not all cells in the inflammatory infiltrate, as well as a reduction in the expression of cell adhesion molecules (intercellular adhesion molecule-1 and vascular adhesion molecule-1) and production of cytokines (interleukin 1β and tumour necrosis factor α). Conclusion: Intra-articular infliximab administration is a viable treatment for a persistent monarthritis resistant to other treatment options and can successfully modulate the inflammatory milieu within the synovial membrane.
dc.description.statementofresponsibilityM J Ahern, D G Campbell, H Weedon, V Papangelis, M D Smith
dc.identifier.citationAnnals of the Rheumatic Diseases, 2008; 67(9):1339-1342
dc.identifier.doi10.1136/ard.2008.090910
dc.identifier.issn0003-4967
dc.identifier.issn1468-2060
dc.identifier.orcidCampbell, D. [0000-0002-1572-9529]
dc.identifier.urihttp://hdl.handle.net/2440/54120
dc.language.isoen
dc.publisherBritish Med Journal Publ Group
dc.source.urihttps://doi.org/10.1136/ard.2008.090910
dc.subjectSynovial Membrane
dc.subjectHumans
dc.subjectSpondylarthropathies
dc.subjectSynovitis
dc.subjectAntirheumatic Agents
dc.subjectAntibodies, Monoclonal
dc.subjectBiopsy
dc.subjectInjections, Intra-Articular
dc.subjectAdult
dc.subjectFemale
dc.subjectInfliximab
dc.titleEffect of intra-articular infliximab on synovial membrane pathology in a patient with a seronegative spondyloarthropathy
dc.typeJournal article
pubs.publication-statusPublished

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