Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction

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dc.contributor.authorGatford, K.
dc.contributor.authorKaur, G.
dc.contributor.authorFalcao-Tebas, F.
dc.contributor.authorWadley, G.
dc.contributor.authorWlodek, M.
dc.contributor.authorLaker, R.
dc.contributor.authorEbeling, P.
dc.contributor.authorMcConell, G.
dc.date.issued2014
dc.description.abstractIndividuals born after intrauterine growth restriction (IUGR) are at an increased risk of developing diabetes in their adult life. IUGR impairs β-cell function and reduces β-cell mass, thereby diminishing insulin secretion. IUGR also induces insulin resistance, with impaired insulin signaling in muscle in adult humans who were small for gestational age (SGA) and in rodent models of IUGR. There is epidemiological evidence in humans that exercise in adults can reduce the risk of metabolic disease following IUGR. However, it is not clear whether adult IUGR individuals benefit to the same extent from exercise as do normal-birth-weight individuals, as our rat studies suggest less of a benefit in those born IUGR. Importantly, however, there is some evidence from studies in rats that exercise in early life might be able to reverse or reprogram the long-term metabolic effects of IUGR. Studies are needed to address gaps in current knowledge, including determining the mechanisms involved in the reprogramming effects of early exercise in rats, whether exercise early in life or in adulthood has similar beneficial metabolic effects in larger animal models in which insulin resistance develops after IUGR. Human studies are also needed to determine whether exercise training improves insulin secretion and insulin sensitivity to the same extent in IUGR adults as in control populations. Such investigations will have implications for customizing the recommended level and timing of exercise to improve metabolic health after IUGR.
dc.description.statementofresponsibilityKathryn L. Gatford, Gunveen Kaur, Filippe Falcão-Tebas, Glenn D. Wadley, Mary E. Wlodek, Rhianna C. Laker, Peter R Ebeling, Glenn K. McConell
dc.identifier.citationAmerican Journal of Physiology - Endocrinology and Metabolism, 2014; 306(9):E999-E1012
dc.identifier.doi10.1152/ajpendo.00456.2013
dc.identifier.issn0193-1849
dc.identifier.issn1522-1555
dc.identifier.orcidGatford, K. [0000-0002-2823-3004]
dc.identifier.urihttp://hdl.handle.net/2440/85214
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.rightsCopyright © 2014 the American Physiological Society
dc.source.urihttps://doi.org/10.1152/ajpendo.00456.2013
dc.subjectIUGR; glucose tolerance; insulin secretion; -cells; insulin sensitivity; training; physical activit
dc.titleExercise as an intervention to improve metabolic outcomes after intrauterine growth restriction
dc.typeJournal article
pubs.publication-statusPublished

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