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SHED: Stem cells from human exfoliated deciduous teeth

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dc.contributor.authorMiura, M.
dc.contributor.authorGronthos, S.
dc.contributor.authorZhao, M.
dc.contributor.authorLu, B.
dc.contributor.authorFisher, L.
dc.contributor.authorRobey, P.
dc.contributor.authorShi, S.
dc.date.issued2003
dc.description.abstractTo isolate high-quality human postnatal stem cells from accessible resources is an important goal for stem-cell research. In this study we found that exfoliated human deciduous tooth contains multipotent stem cells [stem cells from human exfoliated deciduous teeth (SHED)]. SHED were identified to be a population of highly proliferative, clonogenic cells capable of differentiating into a variety of cell types including neural cells, adipocytes, and odontoblasts. After in vivo transplantation, SHED were found to be able to induce bone formation, generate dentin, and survive in mouse brain along with expression of neural markers. Here we show that a naturally exfoliated human organ contains a population of stem cells that are completely different from previously identified stem cells. SHED are not only derived from a very accessible tissue resource but are also capable of providing enough cells for potential clinical application. Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering.
dc.description.statementofresponsibilityMasako Miura, Stan Gronthos, Mingrui Zhao, Bai Lu, Larry W. Fisher, Pamela Gehron Robey and Songtao Shi
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2003; 100(10):5807-5812
dc.identifier.doi10.1073/pnas.0937635100
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.orcidGronthos, S. [0000-0002-6225-3084]
dc.identifier.urihttp://hdl.handle.net/2440/55097
dc.language.isoen
dc.publisherNatl Acad Sciences
dc.source.urihttps://doi.org/10.1073/pnas.0937635100
dc.subjectHippocampus
dc.subjectDentate Gyrus
dc.subjectMitochondria
dc.subjectStromal Cells
dc.subjectStem Cells
dc.subjectTooth, Deciduous
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectMice, SCID
dc.subjectReceptors, Cytoplasmic and Nuclear
dc.subjectTranscription Factors
dc.subjectDNA Primers
dc.subjectStem Cell Transplantation
dc.subjectTransplantation, Heterologous
dc.subjectCell Separation
dc.subjectImmunohistochemistry
dc.subjectIn Situ Hybridization
dc.subjectPolymerase Chain Reaction
dc.subjectBase Sequence
dc.subjectTooth Exfoliation
dc.titleSHED: Stem cells from human exfoliated deciduous teeth
dc.typeJournal article
pubs.publication-statusPublished

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