Subacute toxicity of colistin methanesulfonate in rats: Comparison of various intravenous dosage regimens
Date
2008
Authors
Wallace, S.
Li, J.
Nation, R.
Rayner, C.
Taylor, D.
Middleton, D.
Milne, R.
Coulthard, K.
Turnidge, J.
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Journal article
Citation
Antimicrobial Agents and Chemotherapy, 2008; 52(3):1159-1161
Statement of Responsibility
Stephanie J. Wallace, Jian Li, Roger L. Nation, Craig R. Rayner, David Taylor, Deborah Middleton, Robert W. Milne, Kingsley Coulthard, and John D. Turnidge
Conference Name
Abstract
The relative nephro- and neurotoxicity of colistin methanesulfonate (CMS) was investigated with rats during 7 days of intravenous administration in regimens mimicking twice- and once-daily dosing of a clinically relevant dose for humans. Histological examination revealed more-severe renal lesions with the regimen corresponding to once-daily dosing, indicating that the potential for renal toxicity may be greater with extended-interval dosing.
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