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Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants

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dc.contributor.authorZhou, A.
dc.contributor.authorTaylor, A.E.
dc.contributor.authorKarhunen, V.
dc.contributor.authorZhan, Y.
dc.contributor.authorHypponen, E.
dc.date.issued2018
dc.description.abstractCoffee’s long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (β = −0.0007, 95% C.I. −0.009 to 0.008, P = 0.87; β = −0.001, 95% C.I. −0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P ≥ 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.
dc.identifier.citationScientific Reports, 2018; 8(7526):1-9
dc.identifier.doi10.1038/s41598-018-25919-2
dc.identifier.issn2045-2322
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11541.2/132142
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.fundingJ.J. Mason and H.S. Williams Memorial Foundation CT23158
dc.relation.fundingEconomic and Social Research Council ES/M001660/1
dc.relation.fundingWellcome Trust and Medical Research Council WT095219MA
dc.relation.fundingWellcome Trust and Medical Research Council G1001799
dc.relation.fundingMedical Research Council G0000934
dc.relation.fundingMary Kinross Charitable Trust
dc.relation.fundingHalpin Trust
dc.relation.fundingWellcome Trust 102215/2/13/2
dc.relation.fundingBritish Heart Foundation
dc.relation.fundingCancer Research UK
dc.relation.fundingEconomic and Social Research Council
dc.relation.fundingMedical Research Council
dc.relation.fundingNational Institute for Health Research
dc.relation.fundingMedical Research Council MC_UU_12013/6
dc.rightsCopyright 2018 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made (http://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.1038/s41598-018-25919-2
dc.subjectepidemiology
dc.subjectrisk factors
dc.titleHabitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916198504801831

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