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Insights into the biomedical effects of carboxylated single-wall carbon nanotubes on telomerase and telomeres

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dc.contributor.authorChen, Y.
dc.contributor.authorQu, K.
dc.contributor.authorZhao, C.
dc.contributor.authorWu, L.
dc.contributor.authorRen, J.
dc.contributor.authorWang, J.
dc.contributor.authorQu, X.
dc.date.issued2012
dc.description.abstractBoth human telomeric G-rich and C-rich DNA have been considered as specific drug targets for cancer therapy. However, due to i-motif structure instability and lack of specific binding agents, it remains unclear whether stabilization of telomeric i-motif can inhibit telomerase activity. Single-walled carbon nanotubes (SWNTs) have been reported as the first ligand that can selectively stabilize human telomeric i-motif DNA. Here we report that SWNTs can inhibit telomerase activity through stabilization of i-motif structure. The persistence of i-motif and the concomitant G-quadruplex eventually leads to telomere uncapping and displaces telomere-binding proteins from telomere. The dysfunctional telomere triggers DNA damage response and elicits upregulation of p16 and p21 proteins. This is the first example that SWNTs can inhibit telomerase activity and interfere with the telomere functions in cancer cells. These results provide new insights into understanding the biomedical effects of SWNTs and the biological importance of i-motif DNA.
dc.description.statementofresponsibilityYong Chen, Konggang Qu, Chuanqi Zhao, Li Wu, Jinsong Ren, Jiasi Wang & Xiaogang Qu
dc.identifier.citationNature Communications, 2012; 3(9):1074-1-1074-13
dc.identifier.doi10.1038/ncomms2091
dc.identifier.issn2041-1723
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/2440/88820
dc.language.isoen
dc.publisherNature Publishing Group
dc.rights© 2012 Macmillan Publishers Limited. All rights reserved.
dc.source.urihttps://doi.org/10.1038/ncomms2091
dc.subjectCell Line, Tumor
dc.subjectHela Cells
dc.subjectTelomere
dc.subjectHumans
dc.subjectNanotubes, Carbon
dc.subjectTelomerase
dc.subjectChromatin Immunoprecipitation
dc.subjectCell Proliferation
dc.subjectProtein Binding
dc.subjectG-Quadruplexes
dc.subjectProtein Stability
dc.titleInsights into the biomedical effects of carboxylated single-wall carbon nanotubes on telomerase and telomeres
dc.typeJournal article
pubs.publication-statusPublished

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