Cytotoxin with a Subtilase Domain
| dc.contributor.assignee | ARI Pty Ltd | |
| dc.contributor.author | Paton, J. | |
| dc.contributor.author | Morona, R. | |
| dc.contributor.author | Paton, A. | |
| dc.contributor.other | A.P.T. Patent and Trade Mark Attorneys | |
| dc.date.issued | 2010 | |
| dc.description | PATENT: A. W. Paton, J. C. Paton (Assignee Adelaide Research and Innovation Pty Ltd). AU 2004/201978 A1 filed May 12, 2004; published Jul 7, 2005; Standard Patent Sealed Jun 24, 2010; expiry date May 12, 2024. | |
| dc.description.abstract | A member of a new class of bacterial toxin has been isolated and characterised. The bacterial toxin is of the AB₅ type and is characterised in that it has a subtilase domain. It is cytotoxic to Vero cells, and toxicity in vivo in mice occurs in a number of different sites. Mutation of the serine active residue results in greater than 99% reduction in activity. The protein has been purified and antibodies have been prepared for both the A subunit and B subunits, and ELISA detection methods have been developed. The nucleic acid sequence has been determined and primers specific for the toxin have been used for a preliminary screen of a range of patient samples to ascertain the extent to which the toxin is present. | |
| dc.description.statementofresponsibility | Inventors A. W. Paton, J. C. Paton; Assigned to Adelaide Research and Innovation Pty Ltd; A.P.T. Patent and Trade Mark Attorneys agents to inventors. | |
| dc.description.uri | http://www.lens.org/lens/patent/AU_2004_201978_B2 | |
| dc.identifier.orcid | Paton, J. [0000-0001-9807-5278] | |
| dc.identifier.orcid | Morona, R. [0000-0001-7009-7440] | |
| dc.identifier.patent | 2004201978 | |
| dc.identifier.uri | http://hdl.handle.net/2440/74712 | |
| dc.language.iso | en | |
| dc.subject | AU 2004/201978 B2 | |
| dc.title | Cytotoxin with a Subtilase Domain | |
| dc.type | Patent | |
| pubs.publication-status | Published |