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Nanoparticles produced by ring-opening metathesis polymerization using norbornenyl-poly(ethylene oxide) as a ligand-free generic platform for highly selective in vivo tumor targeting

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dc.contributor.authorGueugnon, F.
dc.contributor.authorDenis, I.
dc.contributor.authorPouliquen, D.
dc.contributor.authorCollette, F.
dc.contributor.authorDelatouche, R.
dc.contributor.authorHéroguez, V.
dc.contributor.authorGrégoire, M.
dc.contributor.authorBertrand, P.
dc.contributor.authorBlanquart, C.
dc.date.issued2013
dc.description.abstractWe described a norbornenyl-poly(ethylene oxide) nanoparticles ligand-free generic platform, made fluorescent with straightforward preparation by ring-opening metathesis polymerization (ROMP). Our method allowed to easily obtain a drug delivery system (DDS) with facilitated functionalization by means of azide−alkyne click chemistry and with a high selectivity for the tumor in vivo, while cellular internalization is obtained without cell targeting strategy. We demonstrated that our nanoparticles are internalized by endocytosis and colocalized with acidic intracellular compartments in two models of aggressive tumoral cell lines with low prognostic and limited therapeutic treatments. Our nanoparticles could be of real interest to limit the toxicity and to increase the clinical benefit of drugs suffering rapid clearance and side effects and an alternative for cancers with poorly efficient therapeutic solutions by associating the drug delivery in the tumor tissue with an acid-sensitive release system.
dc.description.statementofresponsibilityFabien Gueugnon, Iza Denis, Daniel Pouliquen, Floraine Collette, Régis Delatouche, Valérie Héroguez, Marc Grégoire, Philippe Bertrand and Christophe Blanquart
dc.identifier.citationBiomacromolecules, 2013; 14(7):2396-2402
dc.identifier.doi10.1021/bm400516b
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.orcidDenis, I. [0000-0002-2882-4306]
dc.identifier.urihttp://hdl.handle.net/2440/109663
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.rights© 2013 American Chemical Society
dc.source.urihttps://doi.org/10.1021/bm400516b
dc.subjectCell Line, Tumor
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectMice, Nude
dc.subjectMesothelioma
dc.subjectAdenocarcinoma
dc.subjectLung Neoplasms
dc.subjectPolyethylene Glycols
dc.subjectPolymers
dc.subjectAntineoplastic Agents
dc.subjectDrug Delivery Systems
dc.subjectNeoplasm Transplantation
dc.subjectCell Survival
dc.subjectEndocytosis
dc.subjectNanoparticles
dc.subjectPolymerization
dc.subjectAdenocarcinoma of Lung
dc.subjectMesothelioma, Malignant
dc.titleNanoparticles produced by ring-opening metathesis polymerization using norbornenyl-poly(ethylene oxide) as a ligand-free generic platform for highly selective in vivo tumor targeting
dc.typeJournal article
pubs.publication-statusPublished

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