Dialysis-assisted fiber optic spectroscopy for in situ biomedical sensing
Date
2006
Authors
Blazkiewicz, P.
Blazkiewicz, K.
Verhaege, A.
Anissimov, Y.
Roberts, M.S.
Zvyagin, A.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of Biomedical Optics, 2006; 11(1):014033-
Statement of Responsibility
Conference Name
Abstract
A miniature fiber optic spectrometer enclosed within a semipermeable (dialysis) membrane is proposed for in vivo interstitial sensing applications. The semipermeable membrane acts as a molecular filter, allowing only small molecules to pass through to the sampling volume. This filtering, in principle, should enable continuous in vivo drug sensing, removing the necessity for complex microdialysis systems. We use a biological phantom to examine the reliable detection of a fluorescence signal from small dye molecules in the presence of large fluorophores and scatterers. We find that spectral artefacts arising from scatterers and large fluorophores are substantially suppressed, simplifying the spectral analysis. In addition, the measured sampling rate of 157 s is superior to existing in vivo tissue assaying techniques such as microdialysis, which can take tens of minutes.
School/Discipline
Dissertation Note
Provenance
Description
Link to a related website: https://espace.library.uq.edu.au/view/UQ:79856/UQ79856_OA.pdf, Open Access via Unpaywall