The influence of the renin angiotensin system on abnormal expression of nerve growth factor in the spontaneously hypertensive rat.

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dc.contributor.authorJeffreson, S.
dc.contributor.authorRush, R.
dc.contributor.authorZettler, C.
dc.contributor.authorFrewin, D.
dc.contributor.authorHead, R.
dc.date.issued1995
dc.description.abstract1. The levels of the neurotrophic factor, nerve growth factor (NGF) in the mesenteric vascular bed of the spontaneously hypertensive rat (SHR) were greater than those in the corresponding vascular bed of normotensive Wistar-Kyoto rats (WKY). 2. Administration of angiotensin II (200 ng/kg per min, by minipump) for 2 weeks to juvenile WKY rats increased the levels of NGF in the mesenteric vasculature to those seen in untreated SHR. 3. Administration of the angiotensin II receptor antagonists losartan (30 mg/kg per day, p.o.) or PD144277 (10 mg/kg per day, p.o.) to juvenile SHR for 4 weeks reduced the levels of NGF such that they were indistinguishable from the values obtained for normotensive WKY rats. 4. The results confirm the elevated level of NGF in the mesenteric vasculature of the SHR and suggest that angiotensin II may play a role in regulating the abnormal concentrations of the protein in this tissue.
dc.description.statementofresponsibilityS. Jeffreson, R. Rush, C. Zettler, D. B. Frewin and R. J. Head
dc.identifier.citationClinical and Experimental Pharmacology and Physiology, 1995; 22(6-7):478-480
dc.identifier.doi10.1111/j.1440-1681.1995.tb02050.x
dc.identifier.issn0305-1870
dc.identifier.issn1440-1681
dc.identifier.orcidHead, R. [0000-0002-1196-0926]
dc.identifier.urihttp://hdl.handle.net/2440/14363
dc.language.isoen
dc.publisherBlackwell
dc.source.urihttps://doi.org/10.1111/j.1440-1681.1995.tb02050.x
dc.subjectangiotensin II
dc.subjectmesenteric vascular bed
dc.subjectnerve growth factor, spontaneously hypertensive rat
dc.subjectWistar-Kyoto rat
dc.titleThe influence of the renin angiotensin system on abnormal expression of nerve growth factor in the spontaneously hypertensive rat.
dc.typeJournal article
pubs.publication-statusPublished

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