Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition

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dc.contributor.authorSavira, F.
dc.contributor.authorMagaye, R.
dc.contributor.authorScullino, C.V.
dc.contributor.authorFlynn, B.L.
dc.contributor.authorPitson, S.M.
dc.contributor.authorAnderson, D.
dc.contributor.authorCreek, D.J.
dc.contributor.authorHua, Y.
dc.contributor.authorXiong, X.
dc.contributor.authorHuang, L.
dc.contributor.authorLiew, D.
dc.contributor.authorReid, C.
dc.contributor.authorKaye, D.
dc.contributor.authorKompa, A.R.
dc.contributor.authorWang, B.H.
dc.date.issued2021
dc.description.abstractAbstract not available
dc.description.statementofresponsibilityFeby Saviraa, Ruth Magayea, Carmen V. Scullinoc, Bernard L. Flynn, Stuart M. Pitson, Dovile Anderson, Darren J. Creek, Yue Hua, Xin Xionga, Li Huanga, Danny Liew, Christopher Reid, David Kaye, Andrew R. Kompah, Bing Hui Wang
dc.identifier.citationToxicology Letters, 2021; 350:133-142
dc.identifier.doi10.1016/j.toxlet.2021.07.012
dc.identifier.issn0378-4274
dc.identifier.issn1879-3169
dc.identifier.orcidPitson, S.M. [0000-0002-9527-2740]
dc.identifier.orcidLiew, D. [0000-0002-0131-623X] [0000-0003-2064-181X]
dc.identifier.urihttps://hdl.handle.net/2440/135286
dc.language.isoen
dc.publisherELSEVIER IRELAND LTD
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1156693
dc.rights© 2021 Elsevier B.V. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.toxlet.2021.07.012
dc.subjectUremic toxins
dc.subjectDihydroceramide desaturase 1
dc.subjectDes1 inhibitor
dc.subjectSphingolipids
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshUremia
dc.subject.meshCardiovascular Diseases
dc.subject.meshOxidoreductases
dc.subject.meshSphingolipids
dc.subject.meshEnzyme Inhibitors
dc.subject.meshModels, Animal
dc.subject.meshToxins, Biological
dc.subject.meshRenal Insufficiency, Chronic
dc.titleSphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition
dc.typeJournal article
pubs.publication-statusPublished

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