Productive tension: force-sensing and homeostasis of cell-cell junctions
Date
2011
Authors
Gomez, G.A.
McLachlan, R.W.
Yap, A.S.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Trends in Cell Biology, 2011; 21(9):499-505
Statement of Responsibility
Conference Name
Abstract
Cell-cell contacts are major determinants of tissue organization in both health and disease. Adhesive interactions, especially those mediated by classical cadherin receptors, influence cell-cell recognition and tissue patterning during development. Conversely, cadherin dysfunction promotes tumor progression to invasion and metastasis. Over the past three decades, we have learnt a great deal about the molecular mechanisms responsible for cadherin-based cell-cell interactions. Yet our knowledge remains incomplete. The intersection between cell biology and mechanical forces has long been suspected to be an important missing factor in understanding cadherin biology. However, tangible evidence remained elusive until recently, when several reports began to elucidate the role of cadherins and the cytoskeleton in mechanotransduction. In this review, we examine these advances and discuss their implications.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright 2011 Elsevier