Hyperglycemia in pregnancy and developmental outcomes in children at 18-60 months of age: the PANDORA Wave 1 study

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dc.contributor.authorTitmuss, A.
dc.contributor.authorD'Aprano, A.
dc.contributor.authorBarzi, F.
dc.contributor.authorBrown, A.D.H.
dc.contributor.authorWood, A.
dc.contributor.authorConnors, C.
dc.contributor.authorBoyle, J.A.
dc.contributor.authorMoore, E.
dc.contributor.authorO'Dea, K.
dc.contributor.authorOats, J.
dc.contributor.authorMcIntyre, H.D.
dc.contributor.authorZimmet, P.
dc.contributor.authorShaw, J.E.
dc.contributor.authorCraig, M.E.
dc.contributor.authorMaple-Brown, L.J.
dc.date.issued2022
dc.descriptionFirst published online: 4 April 2022
dc.description.abstractThis study aimed to explore the association between hyperglycemia in pregnancy (type 2 diabetes (T2D) and gestational diabetes mellitus (GDM)) and child developmental risk in Europid and Aboriginal women.PANDORA is a longitudinal birth cohort recruited from a hyperglycemia in pregnancy register, and from normoglycemic women in antenatal clinics. The Wave 1 substudy included 308 children who completed developmental and behavioral screening between age 18 and 60 months. Developmental risk was assessed using the Ages and Stages Questionnaire (ASQ) or equivalent modified ASQ for use with Aboriginal children. Emotional and behavioral risk was assessed using the Strengths and Difficulties Questionnaire. Multivariable logistic regression was used to assess the association between developmental scores and explanatory variables, including maternal T2D in pregnancy or GDM.After adjustment for ethnicity, maternal and child variables, and socioeconomic measures, maternal hyperglycemia was associated with increased developmental "concern" (defined as score ≥1 SD below mean) in the fine motor (T2D odds ratio (OR) 5.30, 95% CI 1.77-15.80; GDM OR 3.96, 95% CI 1.55-10.11) and problem-solving (T2D OR 2.71, 95% CI 1.05-6.98; GDM OR 2.54, 95% CI 1.17-5.54) domains, as well as increased "risk" (score ≥2 SD below mean) in at least one domain (T2D OR 5.33, 95% CI 1.85-15.39; GDM OR 4.86, 95% CI 1.95-12.10). Higher maternal education was associated with reduced concern in the problem-solving domain (OR 0.27, 95% CI 0.11-0.69) after adjustment for maternal hyperglycemia.Maternal hyperglycemia is associated with increased developmental concern and may be a potential target for intervention so as to optimize developmental trajectories.
dc.description.statementofresponsibilityAngela Titmuss, Anita D, Aprano, Federica Barzi, Alex D.H. Brown, Anna Wood, Christine Connors, Jacqueline A. Boyle, Elizabeth Moore, Kerin O'Dea, Jeremy Oats, H. David McIntyre, Paul Zimmet, Jonathan E. Shaw, Maria E. Craig and Louise J. Maple-Brown
dc.identifier.citationJournal of Developmental Origins of Health and Disease, 2022; 13(6):695-705
dc.identifier.doi10.1017/S2040174422000101
dc.identifier.issn2040-1744
dc.identifier.issn2040-1752
dc.identifier.orcidBrown, A.D.H. [0000-0003-2112-3918]
dc.identifier.urihttps://hdl.handle.net/2440/138435
dc.language.isoen
dc.publisherCambridge University Press (CUP)
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1078333
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1114760
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1078477
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1194698
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1079438
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1137563
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1136735
dc.rights© The Author(s), 2022. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:// creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1017/s2040174422000101
dc.subjectHyperglycemia
dc.subjectpregnancy
dc.subjectchild development
dc.subjectdiabetes
dc.subject.meshHumans
dc.subject.meshPregnancy Complications
dc.subject.meshDiabetes, Gestational
dc.subject.meshPrenatal Exposure Delayed Effects
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshHyperglycemia
dc.subject.meshPregnancy
dc.subject.meshChild, Preschool
dc.subject.meshInfant
dc.subject.meshFemale
dc.titleHyperglycemia in pregnancy and developmental outcomes in children at 18-60 months of age: the PANDORA Wave 1 study
dc.typeJournal article
pubs.publication-statusPublished

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