Type 2 diabetes mellitus is associated with strongyloides stercoralis treatment failure in Australian Aboriginals

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dc.contributor.authorHays, R.
dc.contributor.authorEsterman, A.
dc.contributor.authorMcDermott, R.
dc.contributor.editorDiemert, D.J.
dc.date.issued2015
dc.description.abstractTo explore the efficacy of ivermectin in the treatment of serologically diagnosed cases of Strongyloides stercoralis (S. stercoralis) infection in an Aboriginal community and to describe factors that may influence the outcome of treatment.Longitudinal study of a group of 92 individuals with serologically diagnosed S. stercoralis treated with ivermectin and followed up over a period of approximately 6 months. Main outcomes were serological titers pre and post treatment, diabetic status, and duration of follow up.Treatment success was achieved in 62% to 79% of cases dependent on the methods employed for the diagnosis of infection and assessment of treatment outcome. Type 2 Diabetes Mellitus (T2DM) was found to be significantly associated with treatment failure in this group for two of the three methods employed.Ivermectin has been confirmed as an effective treatment for S stercoralis infection in this setting. T2DM appears to be an independent risk factor for treatment failure in this population, and plausible mechanisms to explain this observation are presented.
dc.description.statementofresponsibilityRussell Hays, Adrian Esterman, Robyn McDermott
dc.identifier.citationPLoS Neglected Tropical Diseases, 2015; 9(8):e0003976-1-e0003976-10
dc.identifier.doi10.1371/journal.pntd.0003976
dc.identifier.issn1935-2727
dc.identifier.issn1935-2735
dc.identifier.orcidEsterman, A. [0000-0001-7324-9171]
dc.identifier.urihttp://hdl.handle.net/2440/117720
dc.language.isoen
dc.publisherPublic Library Science
dc.rights© 2015 Hays et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.source.urihttps://doi.org/10.1371/journal.pntd.0003976
dc.subjectDiabetes Mellitus, Type 2
dc.titleType 2 diabetes mellitus is associated with strongyloides stercoralis treatment failure in Australian Aboriginals
dc.typeJournal article
pubs.publication-statusPublished

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