Undiagnosed obstructive sleep apnea is independently associated with reductions in quality of life in middle-aged, but not elderly men of a population cohort

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dc.contributor.authorAppleton, S.L.
dc.contributor.authorVakulin, A.
dc.contributor.authorMcEvoy, R.D.
dc.contributor.authorVincent, A.
dc.contributor.authorMartin, S.A.
dc.contributor.authorGrant, J.F.
dc.contributor.authorTaylor, A.W.
dc.contributor.authorAntic, N.A.
dc.contributor.authorCatcheside, P.G.
dc.contributor.authorWittert, G.A.
dc.contributor.authorothers,
dc.contributor.authorAdams, R.J.
dc.date.issued2015
dc.description.abstract<h4>Purpose</h4>Obstructive sleep apnea (OSA) is now highly prevalent but largely undiagnosed. Quality of life is an indicator of both the impact of undiagnosed OSA and the need for strategies to increase OSA diagnosis. We determined age-related impacts of undiagnosed OSA on health-related quality of life (HRQL) and whether this was independent of sleepiness and comorbidities.<h4>Methods</h4>In 2010-2012, 837 participants from the Men Androgen Inflammation Lifestyle Environment and Stress Study (population cohort n = 1869, ≥40 years, Adelaide, Australia), without a prior OSA diagnosis underwent full in-home polysomnography (Embletta X100) and completed the Epworth Sleepiness Scale and SF-36 questionnaire. The effects of the apnea-hypopnea index (AHI) on SF-36 physical (PCS) and mental (MCS) component summary scores and standardized SF-36 scale z-scores were estimated using multiple linear regression adjusted for major comorbidities and sleepiness, stratified by age.<h4>Results</h4>Men ≤69 years demonstrated significant (p < 0.05) decrements/event increase in AHI in PCS score [unstandardized B coefficient (SE) = -0.068 (0.023)], physical functioning, role physical, general health, and vitality z-scores in fully adjusted models. Severe OSA (AHI ≥30) was associated with significant reductions in PCS [B = -4.1 (1.1)] and MCS score [B = -3.6 (1.2)] independent of sleepiness and comorbidities which were attenuated but persisted in men <69 years without depression. In men aged ≥70 years, statistically significant AHI-associated impairments were generally not seen.<h4>Conclusions</h4>Undiagnosed OSA was a major independent contributor to HRQL impairments in men <69 years. Improved strategies to identify undiagnosed OSA are indicated that may require a reduced focus on daytime sleepiness.
dc.description.statementofresponsibilitySarah L. Appleton, Andrew Vakulin, R. Douglas McEvoy, Andrew Vincent, Sean A. Martin, Janet F. Grant, Anne W. Taylor, Nick A. Antic, Peter G. Catcheside, Gary A. Wittert, Robert J. Adams
dc.identifier.citationSleep and Breathing, 2015; 19(4):1309-1316
dc.identifier.doi10.1007/s11325-015-1171-5
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.orcidAppleton, S.L. [0000-0001-7292-9714]
dc.identifier.orcidMcEvoy, R.D. [0000-0002-5759-0094]
dc.identifier.orcidVincent, A. [0000-0002-6428-1070]
dc.identifier.orcidGrant, J.F. [0000-0002-3421-5603]
dc.identifier.orcidTaylor, A.W. [0000-0002-4422-7974]
dc.identifier.orcidCatcheside, P.G. [0000-0002-9372-6788]
dc.identifier.orcidWittert, G.A. [0000-0001-6818-6065]
dc.identifier.orcidAdams, R.J. [0000-0002-7572-0796]
dc.identifier.urihttp://hdl.handle.net/2440/92792
dc.language.isoen
dc.publisherSpringer Verlag
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627227
dc.rights© Springer-Verlag Berlin Heidelberg 2015
dc.source.urihttps://doi.org/10.1007/s11325-015-1171-5
dc.subjectHumans
dc.subjectSleep Apnea, Obstructive
dc.subjectRisk Factors
dc.subjectCohort Studies
dc.subjectCross-Sectional Studies
dc.subjectAge Factors
dc.subjectComorbidity
dc.subjectQuality of Life
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectMale
dc.titleUndiagnosed obstructive sleep apnea is independently associated with reductions in quality of life in middle-aged, but not elderly men of a population cohort
dc.typeJournal article
pubs.publication-statusPublished

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