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Animal models of mucositis: Implications for therapy

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dc.contributor.authorBowen, J.
dc.contributor.authorGibson, R.
dc.contributor.authorKeefe, D.
dc.date.issued2011
dc.description.abstractAlimentary mucositis is a major acute complication in the clinical setting, occurring in a large percentage of patients undergoing cytotoxic therapy. One of the major problems with alimentary mucositis is that the underlying mechanisms behind its development are not entirely understood, which makes it extremely difficult to develop effective interventions. Animal models provide a critical source of knowledge when sampling from patients is unavailable or interventions are yet to be fully tested. This review focuses on the animal models used to increase our understanding of the mechanisms of mucositis and translate new antimucotoxic agents into clinical trials.
dc.description.statementofresponsibilityJoanne M. Bowen, Rachel J. Gibson and Dorothy M. K. Keefe
dc.identifier.citationThe Journal of Supportive Oncology, 2011; 9(5):161-168
dc.identifier.doi10.1016/j.suponc.2011.04.009
dc.identifier.issn1544-6794
dc.identifier.issn1879-596X
dc.identifier.orcidBowen, J. [0000-0003-0876-0031]
dc.identifier.orcidGibson, R. [0000-0002-4796-1621]
dc.identifier.orcidKeefe, D. [0000-0001-9377-431X]
dc.identifier.urihttp://hdl.handle.net/2440/70121
dc.language.isoen
dc.publisherElsevier Oncology
dc.rightsCopyright © 2011 Elsevier Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.suponc.2011.04.009
dc.subjectmucositis
dc.subjectanimals
dc.subjectantineoplastic agents
dc.subjectdisease models
dc.subjectgastric mucosa
dc.subjecthumans
dc.subjectintestinal mucosa
dc.subjectmouth mucosa
dc.titleAnimal models of mucositis: Implications for therapy
dc.typeJournal article
pubs.publication-statusPublished

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