The impact of obesity on oocytes: evidence for lipotoxicity mechanisms

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dc.contributor.authorLinyan Wu, L.
dc.contributor.authorNorman, R.
dc.contributor.authorRobker, R.
dc.date.issued2012
dc.description.abstractObesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality.
dc.description.statementofresponsibilityLinda L.-Y. Wu, Robert J. Norman and Rebecca L. Robker
dc.identifier.citationReproduction, Fertility and Development, 2012; 24(1):29-34
dc.identifier.doi10.1071/RD11904
dc.identifier.issn1031-3613
dc.identifier.issn1448-5990
dc.identifier.orcidNorman, R. [0000-0002-3118-3896]
dc.identifier.orcidRobker, R. [0000-0002-1538-4604]
dc.identifier.urihttp://hdl.handle.net/2440/70615
dc.language.isoen
dc.publisherC S I R O Publishing
dc.rights© CSIRO 2012
dc.source.urihttps://doi.org/10.1071/rd11904
dc.subjectEndoplasmic reticulum stress
dc.subjectpalmitate
dc.titleThe impact of obesity on oocytes: evidence for lipotoxicity mechanisms
dc.typeJournal article
pubs.publication-statusPublished

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