Development of imaging methods / models to study oral vaccination and / or delivery of biologics /
Files
(Published version)
Date
2020
Authors
Jia, Zhengyang
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
thesis
Citation
Statement of Responsibility
Conference Name
Abstract
Oral delivery of biologics/vaccines by nanoparticles has great advantages but faces significant challenges. My PhD project aims at providing better understanding of the uptake and transport of particulate nanocarriers by the intestinal epithelium. To this end, a range of advanced models and imaging techniques were established to investigate both the interactions between nanoparticles and the intestinal mucus as well as the interactions between nanoparticles and intestinal epithelial cells. These models provide platforms to systemically evaluate mucosal interactions, intestinal targeting efficacy and the intestinal absorption of particulate nanocarriers. Ultimately, these models and the knowledge generated through their implementation will benefit the design of particulate nanocarriers for more efficient oral drug delivery and oral vaccination.
School/Discipline
University of South Australia. UniSA Clinical and Health Sciences.
UniSA Clinical and Health Sciences
UniSA Clinical and Health Sciences
Dissertation Note
Thesis (PhD(Biomaterials Engineering and Nanomedicine))--University of South Australia, 2020.
Provenance
Copyright 2020 Zhengyang Jia
Description
1 ethesis (xviii, 147 pages) :
colour illustrations, colour charts.
Includes bibliographical references (pages132-133)
colour illustrations, colour charts.
Includes bibliographical references (pages132-133)
Access Status
506 0#$fstar $2Unrestricted online access