Immunomodulatory mast cells: Negative, as well as positive, regulators of immunity

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dc.contributor.authorGalli, S.
dc.contributor.authorGrimbaldeston, M.
dc.contributor.authorTsai, M.
dc.date.issued2008
dc.description© 2008 Nature Publishing Group, a division of Macmillan Publishers Limited.
dc.description.abstractMast cells can promote inflammation and other tissue changes in IgE-associated allergic disorders, as well as in certain innate and adaptive immune responses that are thought to be independent of IgE. However, mast cells can also have anti-inflammatory and immunosuppressive functions. Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response.
dc.description.statementofresponsibilityStephen J. Galli, Michele Grimbaldeston and Mindy Tsai
dc.identifier.citationNature Reviews Immunology, 2008; 8(6):478-486
dc.identifier.doi10.1038/nri2327
dc.identifier.issn1474-1733
dc.identifier.issn1474-1741
dc.identifier.urihttp://hdl.handle.net/2440/51885
dc.language.isoen
dc.publisherNature Publishing Group
dc.source.urihttps://doi.org/10.1038/nri2327
dc.subjectMast Cells
dc.subjectAnimals
dc.subjectHumans
dc.subjectDisease Models, Animal
dc.subjectInflammation Mediators
dc.subjectImmunologic Factors
dc.subjectImmunity, Cellular
dc.titleImmunomodulatory mast cells: Negative, as well as positive, regulators of immunity
dc.typeJournal article
pubs.publication-statusPublished

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