Anorectal dysfunction increases with time following radiation therapy for carcinoma of the prostate

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dc.contributor.authorYeoh, E.
dc.contributor.authorHolloway, R.
dc.contributor.authorFraser, R.
dc.contributor.authorBotten, R.
dc.contributor.authorDi Matteo, A.
dc.contributor.authorMoore, J.
dc.contributor.authorSchoeman, M.
dc.contributor.authorBartholomeusz, F.
dc.date.issued2004
dc.description.abstract<h4>Objectives</h4>To characterize the prevalence and pathophysiology of anorectal dysfunction up to 2 yr following radiation therapy (RT) for localized carcinoma of the prostate.<h4>Methods</h4>Thirty-eight patients, median age 68 (range 60-82) yr with localized prostate carcinoma randomly assigned to one of two radiation dose schedules, underwent evaluation of the following variables of anorectal function before RT, as well as 4-6 wk and 1 and 2 yr after its completion: (1) symptoms, (2) anorectal motility, (3) anorectal sensory function, and (4) anal sphincteric morphology.<h4>Results</h4>There was a persistent increase in anorectal symptoms after RT. At 2 yr, bowel frequency, urgency, and fecal incontinence were increased in 50%, 47%, and 26% of patients, respectively. After RT, there were progressive reductions of (1) basal anal pressures, (2) anal pressures in response to squeeze and increased intra-abdominal pressure, (3) rectal compliance, and (4) rectal volumes associated with sensory perception and the desire to defecate. The thickness of the external anal sphincter increased with time after RT. No difference was observed between the patients in the two radiation dose schedules.<h4>Conclusions</h4>Anorectal dysfunction following RT for prostate carcinoma is an underestimated cause of morbidity, which progresses with time. The prevalence and pathophysiology of anorectal dysfunction is similar after treatment with two commonly used radiation dose schedules.
dc.identifier.citationAmerican Journal of Gastroenterology, 2004; 99(2):361-369
dc.identifier.doi10.1111/j.1572-0241.2004.04037.x
dc.identifier.issn0002-9270
dc.identifier.issn1572-0241
dc.identifier.urihttp://hdl.handle.net/2440/10478
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.source.urihttps://doi.org/10.1111/j.1572-0241.2004.04037.x
dc.subjectRectum
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectRectal Diseases
dc.subjectRadiotherapy
dc.subjectRadiotherapy Dosage
dc.subjectPrevalence
dc.subjectGastrointestinal Motility
dc.subjectTime Factors
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectAnal Canal
dc.subjectMale
dc.titleAnorectal dysfunction increases with time following radiation therapy for carcinoma of the prostate
dc.typeJournal article
pubs.publication-statusPublished

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