To bead or not to bead: A review of Pseudomonas aeruginosa lung infection models for cystic fibrosis
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Date
2023
Authors
Reyne, N.
McCarron, A.
Cmielewski, P.
Parsons, D.
Donnelley, M.
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Frontiers in Physiology, 2023; 14
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Nicole Reyne, Alexandra McCarron, Patricia Cmielewski, David Parsons, and Martin Donnelley
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Abstract
Cystic fibrosis (CF) lung disease is characterised by recurring bacterial infections resulting in inflammation, lung damage and ultimately respiratory failure. Pseudomonas aeruginosa is considered one of the most important lung pathogens in those with cystic fibrosis. While multiple cystic fibrosis animal models have been developed, many fail to mirror the cystic fibrosis lung disease of humans, including the colonisation by opportunistic environmental pathogens. Delivering bacteria to the lungs of animals in different forms is a way to model cystic fibrosis bacterial lung infections and disease. This review presents an overview of previous models, and factors to consider when generating a new P. aeruginosa lung infection model. The future development and application of lung infection models that more accurately reflect human cystic fibrosis lung disease has the potential to assist in understanding the pathophysiology of cystic fibrosis lung disease and for developing treatments.
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© 2023 Reyne, McCarron, Cmielewski, Parsons and Donnelley. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.