Different levels of neuroprotection by two insulin-like growth factor-I splice variants

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dc.contributor.authorAperghis, M.
dc.contributor.authorJohnson, I.
dc.contributor.authorCannon, J.
dc.contributor.authorYang, S.
dc.contributor.authorGoldspink, G.
dc.date.issued2004
dc.description.abstractWe compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion. This resulted in significant neuroprotection of 88% and 37%, respectively, of motoneurons compared to control plasmid and avulsion-only groups. MGF is markedly more effective than the liver-type, systemic IGF-I for motoneuron survival, suggesting a major role for the peripheral target in adult neuronal maintenance and survival.
dc.description.statementofresponsibilityMichael Aperghis, Ian P. Johnson, John Cannon, Shi-Yu Yang and Geoffrey Goldspink
dc.identifier.citationBrain Research, 2004; 1009(1-2):213-218
dc.identifier.doi10.1016/j.brainres.2004.02.049
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.orcidJohnson, I. [0000-0001-5951-6990]
dc.identifier.urihttp://hdl.handle.net/2440/55744
dc.language.isoen
dc.publisherElsevier Science Bv
dc.source.urihttps://doi.org/10.1016/j.brainres.2004.02.049
dc.subjectAdult
dc.subjectAvulsion
dc.subjectFacial nerve
dc.subjectIGF-I
dc.subjectMGF
dc.subjectMotoneuron
dc.titleDifferent levels of neuroprotection by two insulin-like growth factor-I splice variants
dc.typeJournal article
pubs.publication-statusPublished

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