Polymeric micelles to improve the delivery of poorly soluble antimicrobial agents to bacterial and fungal biofilms /
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(Published version)
Date
2021
Authors
Al-Hawwas, Mina
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Journal Title
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Type:
thesis
Citation
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Abstract
Bacterial and fungal biofilms represent challenging barriers to the effective application of antimicrobials, limiting the successful treatment of infectious diseases. Despite the proven biocidal activity of available antimicrobials, their low solubility and limited biofilm penetrability hamper their activity against biofilms. This thesis reports on development of enzyme and pH-responsive micelles to improve the performance of the clinically important antimicrobial agents chlorhexidine, itraconazole, fluconazole and amphotericin B against biofilms of Staphylococcus aureus and Candida albicans, the leading cause of hospital-acquired infections. The outcomes revealed maximum inhibition and eradication of biofilms using specifically engineered bio-responsive nanocarriers. New opportunities in the prevention and control of biofilm associated infections have been identified.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences
School of Pharmacy and Medical Sciences
Dissertation Note
Thesis (PhD(Medical Science))--University of South Australia, 2021.
Provenance
Copyright 2021 Mina Al-Hawwas
Description
1 ethesis (xiv, 116 pages) :
illustrations (chiefly colour)
Includes bibliographical references (pages 92-111)
illustrations (chiefly colour)
Includes bibliographical references (pages 92-111)
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