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Panic disorder and incident coronary heart disease: a systematic review and meta-analysis protocol

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dc.contributor.authorTully, P.
dc.contributor.authorWittert, G.
dc.contributor.authorTurnbull, D.
dc.contributor.authorBeltrame, J.
dc.contributor.authorHorowitz, J.
dc.contributor.authorCosh, S.
dc.contributor.authorBaumeister, H.
dc.date.issued2015
dc.description.abstractBACKGROUND: The clinical presentation of panic disorder and panic attack overlaps many symptoms typically experienced in coronary heart disease (CHD). Etiological links between panic disorder and CHD are controversial and remain largely tenuous. This systematic review aims to pool together data regarding panic disorder with respect to incident CHD or myocardial infarction. METHODS/DESIGN: Electronic databases (MEDLINE, EMBASE, PsycINFO and SCOPUS) will be searched using a search strategy exploding the topics for CHD and panic disorder. Authors and reference lists of included studies will also be contacted to identify additional published and unpublished studies. Eligibility criteria are as follows: POPULATION: persons without CHD who meet criteria for panic disorder, panic attack, anxiety neurosis or elevated panic disorder symptoms; Comparison: persons without CHD who do not meet criteria for panic disorder, panic attack, anxiety neurosis or elevated panic disorder symptoms; OUTCOME: verified fatal and non-fatal CHD at follow-up; including coronary revascularization procedure, coronary artery disease, and myocardial infarction. Studies adopting self-report CHD will be ineligible. Screening will be undertaken by two independent reviewers with disagreements resolved through discussion. Data extraction will include original data specified as hazard ratios, risk ratios, and original cell data if available. Risk of bias assessment will be undertaken by two independent reviewers. Meta-analytic methods will be used to synthesize the data collected relating to the CHD outcomes with Cochrane Review Manager 5.3. DISCUSSION: This systematic review aims to clarify whether panic disorder is associated with elevated risk for subsequent CHD. An evaluation of the etiological links between panic disorder with incident CHD might inform evidence-based clinical practice and policy concerning triaging chest pain patients, diagnostic assessment, and psychiatric intervention with panic disorder patients.
dc.description.statementofresponsibilityPhillip J Tully, Gary A Wittert, Deborah A Turnbull, John F Beltrame, John D Horowitz, Suzanne Cosh, and Harald Baumeister
dc.identifier.citationSystematic Reviews, 2015; 4(1):33-1-33-8
dc.identifier.doi10.1186/s13643-015-0026-2
dc.identifier.issn2046-4053
dc.identifier.issn2046-4053
dc.identifier.orcidTully, P. [0000-0003-2807-1313]
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]
dc.identifier.orcidTurnbull, D. [0000-0002-7116-7073]
dc.identifier.orcidBeltrame, J. [0000-0002-4294-6510]
dc.identifier.orcidHorowitz, J. [0000-0001-6883-0703]
dc.identifier.orcidCosh, S. [0000-0002-8003-3704]
dc.identifier.urihttp://hdl.handle.net/2440/94455
dc.language.isoen
dc.publisherBioMed Central
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1053578
dc.rights© 2015 Tully et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.source.urihttps://doi.org/10.1186/s13643-015-0026-2
dc.subjectPanic disorder; Panic attack; Anxiety disorder; Anxiety neurosis; Coronary heart disease; Myocardial infarction; Systematic review; Meta-analysis; Protocol; Etiology
dc.titlePanic disorder and incident coronary heart disease: a systematic review and meta-analysis protocol
dc.typeJournal article
pubs.publication-statusPublished

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