Enzyme-catalyzed ring-opening polymerization of unsubstituted ß-lactam
Date
2008
Authors
Schwabe, U.
Kroon, R.
Schonten, A.J.
Kloos, H.
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Journal article
Citation
Macromolecular Rapid Communications, 2008; 29(10):794-797
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Abstract
The synthesis of poly(ß-alanine) by Candida antarctica lipase B immobilized as novozyme 435 catalyzed ring-opening of 2-azetidinone is reported. After removal of cyclic side products and low molecular weight species pure linear poly(ß-alanine) is obtained. The formation of the polymer is confirmed with 1H NMR spectroscopy and MALDI-TOF mass spectrometry. The average degree of polymerization of the obtained polymer is limited to DP=8 by its solubility in the reaction medium. Control experiments with ß-alanine as a substrate confirmed that the ring structure of the 2-azetidinone is necessary to obtain the polymer.
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Link to a related website: https://pure.rug.nl/ws/files/6719465/2008MacromolRapidCommSchwab.pdf, Open Access via Unpaywall
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Copyright 2008 WILEY-VCH