Microwave heating of poly(n-isopropylacrylamide)-conjugated gold nanoparticles for temperature-controlled display of concanavalin A
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Date
2015
Authors
Vasani, R.B.
Janardanan, N.
Prieto Simón, B.
Cifuentes Rius, A.
Bradley, S.J.
Moore, E.
Kraus, T.
Voelcker, N.H.
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ACS applied materials & interfaces, 2015; 7(50):27755-27764
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We demonstrate microwave-induced heating of gold nanoparticles and nanorods. An appreciably higher and concentration-dependent microwave-induced heating rate was observed with aqueous dispersions of the nanomaterials as opposed to pure water and other controls. Grafted with the thermoresponsive polymer poly(N-isopropylacrylamide), these gold nanomaterials react to microwave-induced heating with a conformational change in the polymer shell, leading to particle aggregation. We subsequently covalently immobilize concanavalin A (Con A) on the thermoresponsive gold nanoparticles. Con A is a bioreceptor commonly used in bacterial sensors because of its affinity for carbohydrates on bacterial cell surfaces. The microwave-induced thermal transitions of the polymer reversibly switch on and off the display of Con A on the particle surface and hence the interactions of the nanomaterials with carbohydrate-functionalized surfaces. This effect was determined using linear sweep voltammetry on a methyl-α-d-mannopyranoside-functionalized electrode.
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Copyright 2015 American Chemical Society
Access Condition Notes: Available after 3 December 2016