Effect of surface chemical functionalities on collagen deposition by primary human dermal fibroblasts

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dc.contributor.authorBachhuka, A.
dc.contributor.authorHayball, J.
dc.contributor.authorSmith, L.
dc.contributor.authorVasilev, K.
dc.date.issued2015
dc.description.abstractSurface modification has been identified as an important technique that could improve the response of the body to implanted medical devices. Collagen production by fibroblasts is known to play a vital role in wound healing and device fibrous encapsulation. However, how surface chemistry affects collagen I and III deposition by these cells has not been systematically studied. Here, we report how surface chemistry influences the deposition of collagen I and III by primary human dermal fibroblasts. Amine (NH3), carboxyl acid (COOH), and hydrocarbon (CH3) surfaces were generated by plasma deposition. This is a practically relevant tool to deposit a functional coating on any type of substrate material. We show that fibroblasts adhere better and proliferate faster on amine-rich surfaces. In addition, the initial collagen I and III production is greater on this type of coating. These data indicates that surface modification can be a promising route for modulating the rate and level of fibrous encapsulation and may be useful in informing the design of implantable biomedical devices to produce more predictable clinical outcomes.
dc.description.statementofresponsibilityAkash Bachhuka, John Hayball, Louise E. Smith and K. Vasilev
dc.identifier.citationACS Applied Materials and Interfaces, 2015; 7(42):23767-23775
dc.identifier.doi10.1021/acsami.5b08249
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.orcidBachhuka, A. [0000-0003-1253-8126]
dc.identifier.orcidHayball, J. [0000-0002-3089-4506]
dc.identifier.urihttp://hdl.handle.net/2440/104845
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.granthttp://purl.org/au-research/grants/arc/DP150104212
dc.rights© 2015 American Chemical Society
dc.source.urihttps://doi.org/10.1021/acsami.5b08249
dc.subjectplasma polymerization; surface chemistry; collagen I; collagen III; fibroblasts
dc.titleEffect of surface chemical functionalities on collagen deposition by primary human dermal fibroblasts
dc.typeJournal article
pubs.publication-statusPublished

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